Corporate Workshops (for Vendors)

Thursday and Friday
1:00 - 2:00 PM

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Innovative Applications of Mass Spectrometry in Forensics and Clinical Research

1) An Introduction to Bruker's Chromatography and Mass Spectrometry Portfolio
Joe Anacleto, Bruker Daltonics, Canada

2) MALDI Biotyper - Changing Microbiology: Detection of Resistance Mechanism
Guido Mix, Bruker Daltonik GmbH, Germany

3) Toxtyper - A New Type of Forensic Evidence
Prof. Dr. Thomas Krämer, University of Zürich, Institute of Forensic Medicine, Switzerland

4) Mass Spectrometry Meets Histology: MALDI Imaging in Clinical Research
Dr. Sören Deininger, Bruker Daltonik GmbH, Germany

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Novel Techniques for Forensic Toxicology Screening and Sample Extraction

Hear our customers present their ground-breaking work using the latest innovative approach to forensic toxicology. Reserve your seat today! Novel techniques for Forensic Toxicology Screening and Sample Extraction and Analysis Without Traditional LC for Rapid Throughput of Complex Matrices Including Blood and Urine using QQQ and HR/AM Q Exactive MS Speaker: Marta Kozak, Thermo Fisher Scientific Tox library and workflow Speaker: Bénédicte Duretz, Thermo Fisher Scientific Sample Extraction and Analysis Without Traditional LC for Rapid Throughput of oncology drug measurement with HR/AM Q Exactive MS Speaker: William Clarke, John Hopkins University

Mass Spectrometry Applications for Clinical Research
Russell Watts & Dan Blake

Over the last 10 years many LC/MS/MS applications have been developed by clinical research laboratories and successfully implemented as the technology has become more robust, reliable and affordable. LC/MS/MS offers many technical and financial advantages for the clinical research laboratory and is now seen as a complementary and in some cases a viable alternative to immunoassays. In this workshop we bring together scientists, clinicians and biochemists that hold an interest in the use of Mass Spectrometry in the areas of Clinical Research as we discuss what can achieved with today’s technology and what we can expect in the future.

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Chromatographic Method Development for the LC/MS Users
Dr. James Rudge

The advent and rapid popularity of the MS detectors have led to shorter and narrower columns and subsequently faster chromatographic run times. This presentation covers a brief discussion of chromatographic media, bonded phases and method development in connection with LC/MS and LC/MS/MS technology and requirements.

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Optimizing Mass Spec Analysis and Quantitation

1) Achieve Peak Performance with Agilent Technologies
Kevin McCann, Agilent Technologies

2) Inflammatory Cytokine and Chemokine Profiles of Primary Human Cells Determined with Chip-HPLC-Triple Quadrupole Spectrometry
Christopher Gerner University of Vienna, Institute of Analytical Chemistry, Austria

3) Quality Requirements for Quantitative Clinical Chemistry Proteomics - A Proof-of-Principle Study
Christa Cobbaert, Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Smart Solutions for Clinical Analysis
Giancarlo LA MARCA / Neil LOFTUS / Emmanuel WEY

1) Newborn screening for ADA SCID by MS/MS
Giancarlo LA MARCA - Meyer Children's Hospital - Florence - Italy

2) Next Generation Plasma Collection Technology And Its Impact On Clinical Lc/Ms/Ms Analysis
Neil LOFTUS - Shimadzu MSBU overseas - Manchester - UK

3) The Future Role Of Maldi Mass Spectrometry In The Evolving Challenge Of Antibiotic Resistance
Emmanuel Wey MD - Royal Free Hospital, NHS Foundation Trust, London, UK

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UPLC/MS, A Versatile Tool For The Clinical Laboratory

Join us for an exciting workshop!

UPLC/MS, a Versatile Tool for the Clinical Laboratory.
Chair: Benjamin Dugas, Clinical Business Development Manager, Europe & India, Waters Corporation.

1) Using Liquid Chromatography Mass Spectrometry for the Measurement of Metabolites, Protein and Enzyme Activities
Dr Robert Barouki, Professor of Biochemistry, University Paris Descartes, Head of Metabolic Biochemistry Laboratory, Necker Enfants Maladies Hospital, Paris, France

2) Development of a LC-MS/MS Method for Analysis of Steroids in Blood
Dr Maura Brambilla, Analytical Laboratory Director, Desio Hospital, Desio, Italy

Deficiencies of Deuterium as an Isotopic Label in MS Standards
Scott W. Landvatter, Ph.D.

Stable isotope labeled standards are a critical component in quantification of analytes by LC/MS. Deuterium (2H) is most commonly used. However, deuterium suffers from inherent drawbacks that can limit the accuracy of quantification by LC/MS. These limitations include loss of deuterium in solution and loss of deuterium under mass spec conditions. Without validation of 2H stability, results can be called into question. Second generation LC/MS standards now avoid all the drawbacks of deuterium by incorporating 13C, 15N and, if necessary, 2H in chemically stable non-exchangeable positions. This talk will focus on the limitations of deuterium in LC/MS internal standards, will give examples of inappropriate 2H internal standards and will discuss the 13C/15N labeled improved standards that are now available.