Free Climb or Free Solo: Guidance and Accounts of Establishing Reference Intervals for LDT Mass Spectrometry Assays Kelly Doyle, PhD, DABCC (1,2) Elizabeth L. Frank, PhD, DABCC (1,2) (1) University of Utah Health, Salt Lake City, UT (2) ARUP Laboratories, Inc., Salt Lake City, UT Elizabeth Frank, PhD (Presenter) University of Utah Health / ARUP Laboratories Kelly Doyle, PhD (Presenter) University of Utah Health / ARUP Laboratories Presenter Bio: Elizabeth L. Frank, PhD, is a professor of pathology at the University of Utah School of Medicine and a medical director at ARUP Laboratories, a national reference laboratory operated by the University of Utah, in Salt Lake City. She is certified as a clinical chemist by the American Board of Clinical Chemistry and is a fellow of the AACC Academy. Dr. Frank's clinical and scientific interests are focused on measurement of biogenic amines, porphyrins, and vitamins using HPLC and LC-MS/MS; determination of calculi composition using FTIR; biochemical assessment of nephrolithiasis risk; and use of laboratory test results to evaluate health status. Presenter Bio: I am a board certified clinical chemist (DABCC) with research and clinical interests in mass spectrometry, pediatrics, endocrinology, and toxicology. I am fortunate to be engaged in clinical service and education. I enjoy collaborating on laboratory processes optimization, development of robust methods, and in efforts focused on improving patient care. I received a Ph.D. in Medicinal Chemistry and completed a ComACC accredited fellowship the Department of Pathology at the University of Utah School of Medicine in Clinical Chemistry.