MSACL 2024 Industry Workshop Presentation *This Podium Presentation is occuring in the context of an Industry Workshop that starts at the time below. Its actual start time may be up to 40 minutes later, depending on order of presentation if there are multiple presentations planned by the workshop host. Workshop Host: Thermo Fisher Scientific Day: Thursday March 21 Time: 7:30* Location: Steinbeck 1 (Conference Ctr > 2nd Floor)

Introducing the Orbitrap Astral Mass Spectrometer
	Yue Xuan, PhD, MBA Thermo Fisher Scientific
Presenter Bio: Dr. Yue Xuan is currently the Senior Product Marketing Manager at Thermo Fisher Scientific in Bremen, Germany. Specializing in innovative life science technologies to create unique solutions for omics and translational research, including the high resolution MS1-based quantitative data-independent-acquisition (HRMS1-DIA) workflow and intelligent data acquisition Hybrid-DIA MS to combine biomarker discovery and validation in one step. In her existing role, she initiates and leads global strategic collaborations partnering with top institutions, research centers and industry stakeholders worldwide. In the international cancer moonshot multi-site study, she collaborated with 11 international cancer moonshot initiatives crossing 9 different countries/regions to develop and standardize proteome profiling workflow, proof the application validity of proteomics workflow in clinical studies, pave the way of digitalizing the multi-omics large clinical cohort and turning molecular omics precision medicine into reality. Her contributions have been recognized as she has been selected through a peer-review process to chair sessions at prominent scientific conferences such as Analytica Munich, and she is a regular speaker at international conferences and symposiums. She has a Master of Science degree in Chemistry from Free University Berlin and a doctorate in Analytical Chemistry from Technical University of Dortmund, Germany.

In combination with clinical data and computational analysis, large-cohort proteomics study brings opportunities in improving early diagnosis, refining patient stratification, and predicting/monitoring treatment response. Yet, to achieve meaningful biological insights in large-cohort studies, robust, reproducible, and comprehensive proteome profiling in a high-throughput manner still remains challenging.

Speakers will discuss the performance of the novel Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer for plasma proteomics using the most common plasma sample preparation methods (neat plasma, depleted plasma, and enriched plasma). The Orbitrap Astral MS enables twice the proteome coverage compared to the current commercial mass spectrometers for the same gradient. In addition, with double the throughput, it provides higher proteome coverage. With a throughput of 100 samples/day, we can reproducibly profile ~9000 proteins from human cell line and ~800 proteins from undepleted plasma across multiple instruments and more than 10 consecutive days in a 24/7 operation mode. These results demonstrate this Orbitrap Astral mass platform can comprehensively analyze the proteome of >1000s of sample robustly and reproducibly in a high-throughput manner, addressing the needs in large-cohort studies.