|07:00 - 07:45
Biompatible Solid Phase Microextraction Coupled to MS for Improved Analysis of Biological Fluids
Microextraction using newly developed biocompatible solid phase microextraction (BioSPME) devices can be used to directly sample from complex biological matrices without significant co-extraction of interferences. BioSPME extractions may be coupled with a mass spectrometer directly or analyzed via a standard LC/MS workflow. This sample preparation methodology has evolved into a useful tool for clinical applications. Performing direct MS analysis eliminates time-consuming and costly steps specific to LC and GC separations. This rapid detection technique facilitates fast screening methods and, due to analyte concentration as well as extraction from matrix interferences, often provides highly quantitative results. This workshop will provide an overview of the technique including method development and optimization schemes. Applications including analysis of drugs of abuse, steroids and hormones from a variety of biological matrices including plasma, urine and saliva, will be explored and contrasted to conventional approaches.