Location: Rooms 4-6

Room 4 Chairs: Jen Colby and Jackie Hubbard
Room 5 Chairs: David Herold and Peggi Angel

An overview of the fundamentals that are driving research and development.
This series of Primers on fields within Clinical Mass Spec is free to attend for ALL attendees of the MSACL Congress or Short Courses, including Partial Pass holders.

Takeaways for each session include:

1. Be able to define what the field is, why it matters, and why you personally should care. What is the clinical relevance?
2. Understand what role mass spectrometry plays in this field. Where does mass spec fit in to the big picture of the field?
3. Define any terminology that is specific to this field.
4. Describe how it works, what are the methods and workflows used when studying this field and/or how is it implemented in clinical labs.
5. Identify any challenges to implementation/adoption, where do the opportunities lie?

• Room 4: Metabolomics with Adam Rosebrock
• Room 5: Proteomics with Tim Collier

• Room 4: Lipidomics with Anne Bendt
• Room 5: Glycomics with Richard Drake

• Room 4: Toxicology with Paul Jannetto
• Room 5: Imaging Mass Spectrometry with Ron Heeren

• Room 4: Sample Preparation with Mark Marzinke
• Room 5: Data Science with Alfonso Limon

Location: Room 1

Chair: Hubert Vesper
Overview of ongoing and new CDC’s Standardization Programs

Location: Room 2

Chair: Chris Anderton
Hosted by IMSS.

We will discuss patient-specific effects, sample collection, transport and handling of samples, and tissue preparation when acquiring and interpreting mass spectrometry data. We will especially focus on how these steps effect imaging mass spectrometry data, but many of these topics translate universally across mass spectrometry approaches in general.

This will be an open forum with predefined topics to guide the conversation.

Location: Room 3

Hosted by R/Medicine and moderated by Stephan Kadauke.
Speakers: Stephan Kadauke, Michael Kane, Joseph Rickert

R is a free programming language and a powerful statistical computing environment that is wildly popular among statisticians and data scientists. R is ideally suited for building customized applications for clinical operations, however many (real and perceived) hurdles exist in operationalizing R in healthcare in general, and in the labs in particular. The speakers are the organizers of R/Medicine, an annual conference that aims to promote the R ecosystem in clinical research and practice. This will be a highly interactive session aimed to share insights and experiences both of the discussants and participants, with the aim of facilitating the integration of the R ecosystem into clinical laboratory practice.
Learning objectives:
After completing this activity, participants will be able to:
1. Cite resources available for R and data science education tailored for clinicians and laboratorians.
2. Describe organizational, regulatory, and cultural challenges to integrating the R ecosystem into clinical practice.
3. Discuss best practices for building customized clinical laboratory-developed applications (“lab apps”) in R/Shiny.
Speakers:
Stephan Kadauke, Assistant Professor of Pathology and Laboratory Medicine at the Children’s Hospital of Philadelphia
Michael Kane, Assistant Professor of Biostatistics at Yale University, past Chair of R/Medicine
Joseph Rickert, RStudio PBC, and the R Consortium

Location: Room 4

Hosted by AACC and moderated by Carmen Wiley.
Speakers: Nicole Tolan, Dennis Dietzen, and Stephen Master
Mass spectrometry continues to play a prominent role in the field of laboratory medicine. In this session, each speaker will highlight a clinical case where Mass Spec Analysis has made all the difference in a patient's care and outcome.
Learning objectives:
After completing this activity, the learner will be able to:
1. site examples where mass spectrometry made a difference in patient care
2. describe how mass spectrometry could play an important in their institutions
3. summarize the role of mass spectrometry played in each of these case studies
Speakers:
Nicole Tolan, Assistant Professor of Pathology at Harvard Medical School
Dennis Dietzen, Professor, Pathology & Immunology at Washington University School of Medicine
Stephen Master, Associate Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia

Location: Room 6

Moderator: Salvatore Sechi, NIDDK/NIH
Presenters/Discussants include: Jenny Van Eyk (Cedars Sinai); Wei-Jun Qian (PNNL); Andy Hoofnagle (University of Washington)

The NIDDK recently started a program for developing mass spectrometric assays for proteins and peptides of primary interest to the obesity and diabetes research community. These assays should be highly reproducible, easily transferable to other laboratories, and validated in human plasma or serum. Examples, of proteins and peptides that are of potential interest include insulin, glucagon, c-pepitide, glycated CD59, Adiponectin, Leptin, Resistin, Neuropeptide Y, Alpha-melanocyte-stimulating hormone, Peptide YY, Glucagon-like peptide 1, Ghrelin, Adrenocorticotropin, Corticotropin-releasing hormone, Gastrin, Cholecystokinin, Secretin, Vasoactive intestinal peptide, gastric-inhibitory peptide, gastrin-releasing peptide, motilin, pancreatic polypeptide, RBP4, myostatin, FGF21).

We will discuss how we might proceed in developing, validating, and implementing MS assays of interested to the Obesity and Diabetes community.