EUROPE 2018 Help Us Reach Our Educational Support Goal of $40,000 Educational Travel Grants supported in part by:

Corporate Workshops

**Interested in hosting a Corporate Workshop? Click here.

Corporate Workshops provide an opportunity for MSACL conference attendees to learn more about specific applications or products of interest as presented by sponsoring vendors.

These workshops are offered at no charge to attendees. Sponsoring vendors may request that attendees register. Any hosts offering workshops on Sunday or in the AM may require registration for attendance if they are catered. The PM workshops on Wednesday and Thursday do not require registration (if there are issues regarding this on-site please contact any MSACL employee).

Corporate Workshop holders must be registered for the conference.

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Workshop Assignments

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Wednesday September 12
8:00 - 8:45	Mozart 4-5	OPEN
8:00 - 8:45	Papageno Hall	Thermo Scientific	View Summary	Pre-Register Now
8:00 - 8:45	Paracelsus Hall	SCIEX	View Summary	Pre-Register Now
13:30 - 14:15	Mozart 1-3	Shimadzu	View Summary	Pre-Register Now
13:30 - 14:15	Mozart 4-5	Thermo Scientific	View Summary	Pre-Register Now
13:30 - 14:15	Paracelsus Hall	Agilent Technologies	View Summary	Pre-Register Now
13:30 - 14:15	Trakl Hall	Waters	View Summary	Pre-Register Now
Thursday September 13
8:00 - 8:45	Mozart 4-5	OPEN
8:00 - 8:45	Papageno Hall	OPEN
8:00 - 8:45	Paracelsus Hall	Zivak Technologies	View Summary	Pre-Register Now
13:30 - 14:15	Mozart 4-5	OPEN
13:30 - 14:15	Papageno Hall	Tecan	View Summary
13:30 - 14:15	Paracelsus Hall	OPEN
13:30 - 14:15	Trakl Hall	OPEN

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Corporate Workshop Summaries

Wednesday September 12

@ 8:00 - 8:45 in Papageno Hall with Thermo Scientific

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Targeted Screening and Semi-Quantitation of Drugs in Plasma using High-Resolution Accurate-Mass Detection and Online Sample Preparation Sensitive and selective analytical methods are required in clinical research and forensic toxicology to properly identify a broad range of analytes in complex matrices. The existing methods need to be constantly updated as new compounds, such as designer drugs, become readily available to the illicit drug market. Liquid chromatography coupled to mass spectrometry (LC-MS) has been widely used in this area for years. So far, the preferred detection technology has been triple quadrupole MS for its selectivity in selected reaction monitoring (SRM) mode. However, this approach suffers from the limitation of being able to perform only targeted analysis, while not being useful for unknown screening of new drugs. Come to our educational seminar to learn more. For Research Use Only. Not for use in diagnostic procedures.

@ 8:00 - 8:45 in Paracelsus Hall with SCIEX

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A Clinical Method for Determination of Anti-Infectious Drugs in Serum Anders Blomgren Associate professor at Division of Clinical Chemistry and Pharmacology, Lund University The initiative for this work was taken by physicians from four different disciplines; intensive care, clinics for infection, thorax and transplantation. There has been an unmet need for these types of analysis and especially with short response times. A TDM wish list was produced that containing about 25 different anti-infection drugs and we agreed on starting to develop methods for 7 of them as a first step. During this talk the following will be presented. • Introduction • Analytes – chemistry/properties/stability • LC, MS and Sample prep development and problem solving • Validation with results • Conclusion and future

@ 13:30 - 14:15 in Mozart 1-3 with Shimadzu

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Better Ways of Working in Routine Clinical Pathology Laboratories Healthcare is dynamic and knows no bounds and so routine clinical pathology laboratories face increasing pressures on cost, time and delivering actionable data. At Shimadzu, we believe there's always a way to make life better. This seminar explores a few options to make a difference. 1) Neil LOFTUS - SHIMADZU Corporation, UK Expanding the capability of mass spectrometry in routine clinical pathology – creating better ways of delivering actionable data. 2) Andrea Radeljak, Matea Ivić – KB Merkur, Croatia Automating standardized workflows in the clinical laboratory – using the Shimadzu CLAM-2000 integrated with LC-MS/MS to help increase sample throughput and make it easier for users. 3) Sigrid BAUMGARTEN - Alsachim SAS, France From core expertise of Stable Isotope Labelled Compounds to reagent kits for high quality LCMS data Disclaimer: For Research Use Only. Not for use in diagnostic procedures. Not available in the USA, Canada and China.

@ 13:30 - 14:15 in Mozart 4-5 with Thermo Scientific

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Fully Automated LC-MS – Theory becomes Reality The use of LC-MS in diagnostic pathology has been limited by the complexity of equipment, materials and skills required to establish a fully validated service. A review showed only 19% of respondents were running VitaminD using LC-MS. On the basis that this is the gold standard, a fully validated and simple-to-use mass spectrometer has been a long awaited development. This presentation shares the first practical experience of using the Thermo Scientific™ Cascadion™ SM Clinical Analyser, in a laboratory, where staff have no prior experience of using LC-MS technology. Automated LC-MS/MS: A disruptive technology will improve the quality of care for our patients The LC-MS/MS platform provides solutions to complex analytical problems for clinical routine laboratories. This development started decades ago and the technology has proven to deliver reliable results with unreached specificity in TDM, DoA testing, endocrine diagnostics and newborn screening. In this presentation the concept of a fully integrated and automated LC-MS/MS is described. Special focus is on features of the Thermo Scientific™ Cascadion™ SM Clinical Analyzer that can overcome the limitations of open systems. Product IVD/CE-marked. Product not 510(k) cleared and not yet available for sale in the US.

@ 13:30 - 14:15 in Paracelsus Hall with Agilent Technologies

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Developing and Delivering Advanced Protein Biomarker Tests for an Era of Precision Medicine Speaker: Prof. Stephen R Pennington, Senior Fellow UCD Conway Institute, University College Dublin, Ireland This presentation will address the key issues around the development of protein signatures in areas of significant unmet clinical need and potential strategies for the delivery and implementation of multiplexed protein biomarkers in a diagnostic setting. View abstract For Research Use Only. Not for use in diagnostic procedures.

@ 13:30 - 14:15 in Trakl Hall with Waters

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Determination of Steroid Hormones in biological matrices by Tandem Mass Spectrometry The determination of steroid hormones in biological matrices requires high analytical sensitivity and is particularly challenging due to analytical interferences from structurally related steroid hormones and synthetic derivatives. LC-MS/MS can provide the analytical sensitivity, selectivity and precision required to enable accurate quantification of organic compounds in human biological liquid matrices. As a leading clinical LC-MS/MS solutions partner, Waters is a trusted provider of in vitro diagnostic medical devices, consumables, informatics, and support services for high performance LC-MS/MS systems. Join us at this workshop to gain insights into how our customers have addressed the challenging analysis of steroid hormones by implementing Waters solutions. LC-MS/MS Analysis of Steroids in the Clinical Laboratory Dr. Brian Keevil, University Hospital of South Manchester , Biochemistry Department Download Dr. Keevil's abstract For Research Use Only. Not for use in diagnostic procedures. Learn more on Waters Solutions for LC/MS Analysis

Thursday September 13

@ 8:00 - 8:45 in Paracelsus Hall with Zivak Technologies

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From Primary Sample Tubes to Results: World’s First Fully Automated Sample Preparation and Injection UHPLC System Zivak Technologies is delivering solution to manual sample preparation related problems of chromatography analysis and enabling clinical laboratories to make the most of their MS/MS instruments by full automatization. Fully automated Zivak analyzers allow you to get results from primary sample tubes without any user intervention. After the tubes are placed in the sample tray and the analysis is started on the computer, the robotic arms carry out all sample preparation steps, inject the prepared sample to MS/MS and chromatographic run starts. With Zivak analyzers, opening the sample tubes’ caps is never required. Attend the workshop and listen a detailed review of World’s First Walk Away Sample Preparation and Injection UHPLC System Multitasker and Zivak’s Revolutionary VD-200, Fully Automated Vitamin D2-D3 UHPLC Analyzer from Prof. Dr. Ahmet Ceyhan Gören.

@ 13:30 - 14:15 in Papageno Hall with Tecan

Meet our experts in MS sample prep who will present innovative workflows using positive pressure workstations and liquid handling platforms to prep samples for clinical proteomics and steroid analysis. Semi-automated sample processing for clinical proteomics Stefan Loroch, Leibniz Institute for Analytical Sciences (ISAS), Proteomics Facility Powerful automated multi-steroid extraction via positive pressure and liquid handling platform for LC-MS analysis Dr. Christian Scherling, Tecan Germany, MS Sample Prep Application Specialist