Corporate Workshops

Thursday
8:00 - 8:40 AM

Thursday and Friday
2:30 - 3:30 PM

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Time Matters. Simplify Workflow Routines
Edward Goucher, Thermo Fisher Scientific  

Discover four medical devices for general clinical use: Thermo Scientific™ Prelude MD™ HPLC, Thermo Scientific™ Prelude LX-4 MD™ HPLC, Thermo Scientific™ Endura MD™ mass spectrometer, and Thermo Scientific™ ClinQuan MD™ Software. Clinical laboratories can use these devices to build their own lab developed tests (LDT). Various example compounds and workflows will be used to demonstrate the robustness and time efficiency of these new medical devices. For in vitro diagnostic use. Not available in all countries.

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Smart Solutions: Fully Automated Systems for Your Laboratory Applications

1. TDMPREP - Centrifugation Free Sample Preparation with Magnetic Beads!
Mario WUTTKE, Magnamedics, Netherlands

2. New Developments in NBS using DBS for Metabolic Profiling including Steroids
Prof David C. KASPER, MedUni Vienna/ARCHIMEDlife, Austria

3. New LCMS-8060: Opens Up the Way for New Applications
Stephane MOREAU, Shimadzu Europa Gmbh, Germany

4. Fully Automated System including Sample Preparation
Stephane MOREAU, Shimadzu Europa Gmbh, Germany

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TDMPREP - Centrifugation Free Sample Preparation with Magnetic Beads!
Mario WUTTKE, Magnamedics, Netherlands

Pre-Register for this Workshop

New Developments in NBS using DBS for Metabolic Profiling including Steroids
Prof David C. KASPER, MedUni Vienna/ARCHIMEDlife, Austria

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New LCMS-8060: Opens Up the Way for New Applications & Fully Automated System including Sample Preparation
Stephane MOREAU, Shimadzu Europa Gmbh, Germany

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Identifying Unknown Unknowns with High Resolution Accurate Mass MS in Toxicology
Robert Mistrik, HighChem

Despite the increasing use of modern high resolution mass spectrometers, toxicological analysis is hindered by an inability to identify detected compounds effectively. We will present an advanced computational and database framework leading to the much anticipated increase in coverage of toxicologically relevant compounds and their transformation products, taking into account all the important experimental and calculated information necessary for efficient and reliable identifications. Those methods are exploiting combination of library searching methods, both spectral (mzCloud) and structural (PubChem, ChemSpider), with computational techniques like quantum chemical methods, precursor ion fingerprinting, fragment ion search and others.

Workshops on StreamSelect, Metabolic Workflows and Sample Prep with AssayMAP Bravo

1. Introducing the New Agilent StreamSelect LC/MS System
Pete Christensen, PhD, Agilent Technologies, UK

2. Metabolomic Workflows for Clinical Research-demonstrating a tool to address investigation of inborn metabolic errors
Dr. Holger Stalz, Agilent Technologies, Switzerland

3. Rethink your Protein Sample Preparation Strategy with Agilent AssayMAP Bravo
Moritz Wagner, PhD, Agilent Technologies, Germany

Introducing the New Agilent StreamSelect LC/MS System
Pete Christensen, PhD, Agilent Technologies, UK

Metabolomic Workflows for Clinical Research - Demonstrating a Tool to Address Investigation of Inborn Metabolic Errors
Dr. Holger Stalz, Agilent Technologies, Switzerland

Rethink your Protein Sample Preparation Strategy with Agilent AssayMAP Bravo
Moritz Wagner, PhD, Agilent Technologies, Germany

Scientific and Instrumental Advances in Dried Blood Spot Analysis
Christophe Stove and Bert Ooms

Dried blood spot analysis is emerging as a useful tool for quantitative bioanalysis, particularly for micro volumes of blood or plasma. DBS enables remote sampling in low resource settings or at-home sampling for out-patients. The micro-volume concept helps to reduce lab-animal use and allows use of finger prick instead of venous puncture, making the technique easier applicable for children. However, issues such as the effect of hematocrit on spot size have hindered broad acceptance of DBS for routine bioanalysis. Recent innovations have addressed these issues and will be presented and discussed in this workshop by professor Christophe Stove (Gent University). An introduction to the new DBS autosampler from Spark Holland will be presented by Bert Ooms, principal scientist(Spark Holland).

Scientific and Instrumental Advances in Dried Blood Spot Analysis
Christophe Stove

Dried blood spot analysis is emerging as a useful tool for quantitative bioanalysis, particularly for micro volumes of blood or plasma. DBS enables remote sampling in low resource settings or at-home sampling for out-patients. The micro-volume concept helps to reduce lab-animal use and allows use of finger prick instead of venous puncture, making the technique easier applicable for children. However, issues such as the effect of hematocrit on spot size have hindered broad acceptance of DBS for routine bioanalysis. Recent innovations have addressed these issues and will be presented and discussed in this workshop by professor Christophe Stove (Gent University).

Scientific and Instrumental Advances in Dried Blood Spot Analysis
Bert Ooms

An introduction to the new DBS autosampler from Spark Holland will be presented by Bert Ooms, principal scientist(Spark Holland).

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UPLC-MS/MS-Based Studies of Vitamin D Metabolism: Lessons Learned from CYP24A1 Knockout Mice and Men
Martin Kaufmann, Queen’s University, Kingston Canada

Vitamin D function in the body is partly regulated by catabolism of 1,25-(OH)2D and 25-OH-D by CYP24A1. We have developed a sensitive assay using ACQUITY/TQ-S instruments to quantitate metabolites formed by CYP24A1 including 24,25-(OH)2D3, in addition to 25-OH-D. The talk will focus on the application of our assay to a unique combination of samples from CYP24A1-null mice and patients with inactivating mutations to CYP24A1 (Idiopathic Infantile Hypercalcemia) as well as subjects taking vitamin D supplements. We reveal that the ratio of 25-OH-D3:24,25-(OH)2D3 is a useful tool to predict the presence of CYP24A1 mutations as well vitamin D deficiency.

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Mass Spectrometry Applications for Clinical Research
Dr Robert Graham and Dr Michael Wright

In this workshop we bring together scientists, clinicians and biochemists that hold an interest in the use of Mass Spectrometry in the areas of Clinical Research as we discuss what can achieved with today’s technology and what we can expect in the future. We have two speakers delivering this workshop. Dr Robert Graham is Senior Lecturer in Clinical Proteomics at the University of Manchester, UK. Dr Graham will discuss the use of advanced accurate mass MS technologies in ovarian cancer biomarker research We also have Dr Michael Wright, from the Prince of Wales Hospital, Sydney, Australia Dr Wright is Senior Leader of clinical Chemistry and Endocrinology. In the workshop he will discuss novel and advanced MS technologies specifically with respect to their use in reducing background and matrix effects in sample analysis.

Workshops on Navigating Sample Prep Techniques & Leveraging the Power of Microsampling

1. Navigating Sample Preparation Techniques in the Clinical LCMS Laboratory
Sean Orlowicz Manager- PhenoLogix
Have you ever asked yourself, "Which Sample Prep Technique is right for this analysis?" If so, you are not alone. In this talk we will investigate, through case studies, some differences between common sample preparation techniques.

2. Leverage the Power of Microsampling to Benefit Both Your Patient and Your Laboratory
James Rudge Ph.D. -Senior Business Development Manager – Europe
Hospital, clinical, and wellness/biomarker screening labs are using Mitra Microsampling to provide a better, more convenient experience to their patients, while at the same time reducing costs and streamlining workflows. In this workshop, we will discuss the details of an at-home sampling workflow, from collection through analysis, including the optimization and automation of extractions for clinical samples

Workshops on Method Automation

1. Automation and Validation of a SPE Method for the Analysis of 23 Opioids, Cocaine, and Metabolites in Urine with UHPLC-MS/MS
Maria del Mar Ramirez Fernandez, National Institute of Criminology and Criminalistics, Belgium

2. Automated LC-MS/MS methods for Clinical Diagnostics - Realized for Therapeutic Drug Monitoring and Vitamins
Dr. Silvia Bächer, R&D, RECIPE Chemicals + Instruments GmbH

3. Automated SPE Method Development using StrataTM – X 96-Well SPE Method Development Plates in Conjunction with a Tecan Freedom EVO® Liquid Handling Platform Sean Orlowicz, Manager- Phenomenex

Customer experience and commercial insights will be presented for applying automated MS sample preparation in areas of clinical and forensic sample testing, such as therapeutic drug monitoring, DOA- and Vitamin testing. We have pulled together speakers that will present most relevant automated methods and provide guidance on successfully implementing lab established and kit based methodologies.

Automation and Validation of a SPE Method for the Analysis of 23 Opioids, Cocaine, and Metabolites in Urine with UHPLC-MS/MS
Maria del Mar Ramirez Fernandez, National Institute of Criminology and Criminalistics, Belgium

Automated LC-MS/MS methods for Clinical Diagnostics - Realized for Therapeutic Drug Monitoring and Vitamins
Dr. Silvia Bächer, R&D, RECIPE Chemicals + Instruments GmbH

Automated SPE Method Development using StrataTM – X 96-Well SPE Method Development Plates in Conjunction with a Tecan Freedom EVO® Liquid Handling Platform
Sean Orlowicz, Manager- Phenomenex